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KMID : 0357919810150030238
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Korean Journal of Pathology
1981 Volume.15 No. 3 p.238 ~ p.244
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Study on Liver Function and Serum Immunoglobulin Levels in Type B and Type Non-B Hepatitis
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Abstract
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The author investigated the findings of the liver function tests and serum
immunoglobulin 1evels in 25 cases of acute hepatitis, 22 cases of chronic hepatitis and
20 cases of healthy controls in Busan National University Hospital during Jan 1980 and
Dec. 1980. Diagnosis was confirmed clinically and pathologically in all the patients.
Serum HBsAg was detected by reverse passive hemagglutinnation tests(R-PHA). Serum
immunoglobulins were measured by single radial immunodiffusion method. Total protein
and albumin daterminations were performed by Biuret and dye binding method(BCG),
respectively. SGOT and SGPT were analyzed by Reitman-Frankel method and TTT
was measured by Maclagen method. Total bilirubin was measured by modification of the
standard Jendrassik-Grof method.
The results obtained were summarized as follow :
1) The activities of SGOT and SGPT, the levels of serum total bilirbin and IgG ware
significantly higher in type B acute hepatitis than in type non-B one.
2) The levels of IgG and IgM were significantly higher in type non-B chronic hepatitis
than in type B one.
On the basis of the findings mentioned above, it is suggested that serum
immunoglobulin determinations may be useful for differentiation between type B
hepatitis and type non B hepatitis.
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